Using dendrimers to study cancer metastasis.
Many reports suggest that cell surface carbohydrates serve a critical function in malignant transformation and metastasis. We are developing artificial carbohydrate arrays to mimic and interfere with metastasis. Our goal is to advance fundamental knowledge regarding the role of protein-carbohydrate and carbohydrate-carbohydrate interactions in the metastatic spread of cancer. Concurrently, new therapeutic agents to arrest cancer metastasis may also emerge.
Biochemistry, Bioinorganic, Chemical Biology, Organic