Research Projects
Dendrimer characterization
FIgure 4
The evaluation of dendrimer properties is another area of macromolecular chemistry that is of interest to us. To study the relative locations and the dynamic nature of dendrimer endgroups, we have functionalized dendrimers with varying amounts of spin-labels. EPR spectra of TEMPO-labeled G(4)-PAMAM dendrimers (Figure 4) suggest that termini are randomly distributed on heterogeneously-functionalized dendrimers. Additional EPR studies with other generations of dendrimers and with non-random surface spin-labeling distributions are underway.
Publications
Morgan JR, Cloninger MJ
, "Synthesis of Carbohydrate-linked Poly(polyoxometalate) PAMAM Dendrimers
." J. Polym. Sci. A., Polym. Chem. 43 3059-3066 (2005)
Walter ED, Sebby KB, Usselman RJ, Singel DJ, Cloninger MJ
, "Characterization of Heterogeneously Functionalized Dendrimers by Mass Spectrometry and EPR Spectroscopy
." J. Phys. Chem. B. 109 21532-21538 (2005)
Morgan JR, Cloninger MJ
, "Heterogeneously Functionalized Dendrimers
." Curr. Op. Drug Disc. Dev. 5 966–973 (2002)
Personnel:
Mary Cloninger
Keywords:
Chemical Biology, Organic, Spectroscopy, Structure, Synthesis
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