Montana State University
Department of Chemistry and Biochemistry
230 Chemistry and Biochemistry & Building
Bozeman, MT 59717

Email: fmus@chemistry.montana.edu

Research Interests


  • Understanding molecular pathway leading to the activation of the [Fe-Fe]-hydrogenases and biochemical analysis of the interactions between the proteins involved in the [Fe-Fe]-hydrogenase maturation process
  • Characterization of new [Fe-Fe]-Hydrogenases

New class of CO2 fixing and carboxylating enzymes

Examine mechanisms of novel carboxylase enzymes involved in the microbial metabolism of alkenes and epoxides



Ph.D. Molecular Biology and Biotechnologies, University Aix-Marseille II (France)



Montana State University, Department of Biochemistry


Montana State University, Department of Microbiology


Metabolic Explorer, Green Chemistry Company (France)


Stanford University, Carnegie Institution of Washington, Department of Plant Biology


CEA-Cadarache (France), Life Sciences Division (France)


  1. “Physiological and molecular analysis of carbon source supplementation and pH stress-induced lipid accumulation in the marine diatom Phaeodactylum tricornutum.”
    Mus F., Toussaint J.P, Cooksey C.E., Fields M.W., Gerlach R., Brent P.M. and Carlson R.P. (2013)
    Applied Microbiology and Biotechnology 97(8):3625-42
  2. “Altered Fermentative Metabolite Flow in Chlamydomonas reinhardtii Mutants Lacking PFL1 and both PFL1 and ADH1”
    Catalanotti C., Subramanian V., Dubini A., Yang W., Magneschi L., Mus F., Seibert M., Posewitz M.C and Grossman A.R. (2012)
    Plant Cell 24(2):692-707
  3. “A Mutant in the ADH1 Gene of Chlamydomonas reinhardtii Elicits Metabolic Restructuring During Anaerobiosis”
    Magneschi L., Catalanotti L., Subramanian V., Dubini A., Yang W., Mus F., Posewitz M.C, Seibert M., Perata P., Grossman A.R. (2012)
    Plant Physiology 23(158):1293-1305
  4. “Use of Sodium Bicarbonate to Stimulate Triacylglycerol Accumulation in Chlorophyte Scenedesmus sp. and diatom Phaeodactylum tricornutum”
    Gardner R., Cooksey K.E, Mus F., Macur R., Moll K., Eustance E., Carlson R.P, Gerlach R, Fields M.W, Peyton B.M. (2012)
    Journal Applied Phycology 24:1311–1320
  5. “Genetic Disruption both Chlamydomonas reinhardtii [FeFe]-Hydrogenases: Insight into the Role of HYDA2 in H2 Production”
    Meuser J.M, D’Adamo S., Jinkerson R.E, Mus F., Yang W., Ghirardi M.L, Seibert M., Grossman A.R, and Posewitz M.C. (2012)
    Biochemical and Biophysical Research Communications 417(2):704-9
  6. “Reverse Genetics in Chlamydomonas: A Platform for Isolating Insertional Mutants”. Gonzalez-Ballester D, Pootakham W, Mus F, Yang W, Catalanotti C, Magneschi L, de Montaigu A, Higurera JJ, Prior M, Galvan A, Fernandez E, Grossman AR (2011).
    Plant Methods 7(1):24
  7. "Flexibility in anaerobic metabolism as revealed in a mutant of Chlamydomonas reinhardtii lacking hydrogenase activity”.
    Dubini A., Mus F., Seibert M., Grossman A. R. and Posewitz M. C (2009)
    Journal of Biological Chemistry 284(11):7201-13
  8. “Characterization of Nda2, a plastoquinone-reducing type II NAD(P)H dehydrogenase in chlamydomonas chloroplasts”
    Desplats C*, Mus F*, Cuiné S, Billon E, Cournac L, Peltier G (2009)
    Journal Biologycal Chemistry 284(7):4148-57
    (*both authors contributed equally to this work)
  9. “Producing Hydrogen By Heterologous Expression Of A Type II Nad (P)H Deshydrogenase In Chlamydomonas”
    Bernard L., Mus F., Simon-Desplats C., Cuiné S., Cournac L. and Peltier G. (2011)
    Patent Application Number : 20080199928 / US 7,919,292,B2
  10. “Anaerobic Acclimation in Chlamydomonas reinhardtii: Anoxic Gene Expression, Hydrogenase Induction and Metabolic Pathways”
    Mus F., Dubini A., Seibert M., Posewitz M. C. and Grossman A. R. (2007)
    Journal of Biological Chemistry 282(35): 25474-86
  11. “Agrobacterium tumefaciens type II NADH dehydrogenase. Characterization and interactions with bacterial and thylakoid membranes”
    Bernard L., Desplats C., Mus F., Cournac L., Cuine S. and Peltier G. (2006)
    FEBS Journal, 273 (15): 3625-37
  12. “Genotypic variation in induced resistance and induced susceptibility in the peach-Myzus persicae aphid system”
    Sauge M.H., Mus F., Lacroze J.P., Pascal T., Kervella J. and Poessel J.L. (2006)
    OIKOS 113(2): 305-313
  13. "Inhibitor studies on non-photochemical plastoquinone reduction and Hygrogen photoproduction in Chlamydomonas reinhardtii”
    Mus F., Cournac L., Cardettini V., Caruana A. and Peltier G. (2005)
    Biochemical  and Biophysica Acta, 1708 (3): 322-332
  14. “Limiting steps of hydrogen production in Chlamydomonas reinhardtii and Synechocystis PCC 6803 as analysed by light-induced gas exchange transients”
    Cournac L., Mus F., Bernard L., Guedeney G., Vignais P. and Peltier G. (2002)
    International Journal of Hydrogen Energy 27: 1229-1237