Montana State University

Department of Chemistry and Biochemistry

Martin Teintze
HIV receptor and co-receptor interactions

Martin Teintze

Associate Professor
Office: Room 218 Chemistry and Biochemistry Building
Lab: Room 158 Chemistry and Biochemistry Building


P.O. Box 173400
Bozeman, MT 59717
Ph: 406 994 5390
Fax: 406 994 5470
mteintze@montana.edu
Research Group Website
Research Summary

B.S.: 1976 Caltech
Ph.D.: 1981 U.C. San Diego
Postdoc.: 1981-82 University of Gottingen, Germany
Postdoc.: 1983-85 SUNY Stony Brook, NY


Courses:
· BCH 444 BIOCHEMICAL METHODS IN MOLECULAR BIOLOGY
· MEDS 514 MOLECULAR & CELLULAR BIOLOGY

Awards and Professional Activities:
1983-85: National Research Service Award (NIH)


Design of small-molecule CXCR4 antagonists for HIV and cancer treatment:

CXCR4 is a G-protein coupled receptor for the chemokine CXCL12 (SDF-1), which is involved in cell migration and proliferation. It is also a co-receptor used by the X4 strains of HIV, which predominate at later stages of infection, and is required for their entry into target cells. We are designing and synthesizing non-peptide small molecule inhibitors of CXCR4 based on modeling studies. Lead compounds that compete with known CXCR4 antagonists, such as the peptide T-140, are being investigated for their ability to inhibit HIV infection in vitro, and to inhibit tumor cell metastasis in vitro and in a mouse model.

Selected Publications

Cheung, G.Y., Rigby, K., Wang, R., Queck, S.Y., Braughton, K.R., Whitney, A.R., Teintze, M., DeLeo, F.R., and Otto, M. :
Staphylococcus epidermidis strategies to avoid killing by human neutrophils.
PLoS Pathog. 6(10): pii: e1001133 (2010)

Wilkinson, R.A., Pincus, S.H., Shepard, J.B., Walton, S.K., Bergin, E.P., Labib, M. and Teintze, M. :
Novel compounds containing multiple guanide groups which bind the HIV co-receptor CXCR4.
Antimicrob. Agents Chemother. 55:255-263 (2011)

Wilkinson, R.A., Pincus,S.H., Song, K., Shepard, J.B., Weaver, A., Labib, M.E., and Teintze, M. :
Improved guanide compounds which bind the CXCR4 co-receptor and inhibit HIV infection.
Bioorg. Med. Chem. Lett. published online ahead of print: dx.doi.org/10.1016/j.bbr.2011.03.031(2013)

Keywords:
Biochemistry


Development of broad-spectrum antibacterial compounds:

Compounds with multiple biguanide groups such as chlorhexidine, alexidine, and PHMB are used as topical antimicrobials in a variety of settings. We have synthesized a series of small molecules with guanide, biguanide, and arylguanide functional groups that have comparable broad spectrum antibacterial activity, but lower cytotoxicity towards mammalian cells. We are investigating their mechanism of action and further optimizing their structures.

Keywords:
Biochemistry



Full publication list via PubMed     Full publication list via Web of Science