HIV receptor and co-receptor interactions
Office: Room 218 Chemistry and Biochemistry Building
Lab: Room 158 Chemistry and Biochemistry Building
P.O. Box 173400
Bozeman, MT 59717
Ph: 406 994 5390
Fax: 406 994 5470
Research Group Website
B.S.: 1976 Caltech
Ph.D.: 1981 U.C. San Diego
Postdoc.: 1981-82 University of Gottingen, Germany
Postdoc.: 1983-85 SUNY Stony Brook, NY
· BCH 444 BIOCHEMICAL METHODS IN MOLECULAR BIOLOGY
· MEDS 514 MOLECULAR & CELLULAR BIOLOGY
Awards and Professional Activities:
1983-85: National Research Service Award (NIH)
Design of small-molecule CXCR4 antagonists for HIV and cancer treatment:
CXCR4 is a G-protein coupled receptor for the chemokine CXCL12 (SDF-1), which is involved in cell migration and proliferation. It is also a co-receptor used by the X4 strains of HIV, which predominate at later stages of infection, and is required for their entry into target cells. We are designing and synthesizing non-peptide small molecule inhibitors of CXCR4 based on modeling studies. Lead compounds that compete with known CXCR4 antagonists, such as the peptide T-140, are being investigated for their ability to inhibit HIV infection in vitro, and to inhibit tumor cell metastasis in vitro and in a mouse model.
Cheung, G.Y., Rigby, K., Wang, R., Queck, S.Y., Braughton, K.R., Whitney, A.R., Teintze, M., DeLeo, F.R., and Otto, M. :
Wilkinson, R.A., Pincus, S.H., Shepard, J.B., Walton, S.K., Bergin, E.P., Labib, M. and Teintze, M.
Wilkinson, R.A., Pincus,S.H., Song, K., Shepard, J.B., Weaver, A., Labib, M.E., and Teintze, M.
Development of broad-spectrum antibacterial compounds:
Compounds with multiple biguanide groups such as chlorhexidine, alexidine, and PHMB are used as topical antimicrobials in a variety of settings. We have synthesized a series of small molecules with guanide, biguanide, and arylguanide functional groups that have comparable broad spectrum antibacterial activity, but lower cytotoxicity towards mammalian cells. We are investigating their mechanism of action and further optimizing their structures.
Chemistry & Biochemistry
103 Chemistry and Biochemistry Building
PO Box 173400
Bozeman, MT 59717