Bioorganic and Macromolecular
Office: Room 351 Chemistry Biochemistry Building
Labs: Rooms 344 and 346 Chemistry Biochemistry Building
P.O. Box 173400
Bozeman, MT 59717
Research Group Website
B.S.: 1991 Texas Christian University, Fort Worth, TX
Ph.D.: 1996 University of Wisconsin-Madison
Postdoc.: 1996-1997 University of Wisconsin Enzyme Institute (with Prof. Perry Frey)
Postdoc.: 1997-1999 University of California-Irvine (with Prof. Larry Overman)
· CHMY 333 HONORS ORGANIC CHEMISTRY II
· CHMY 533 PHYSICAL ORGANIC CHEMISTRY
Awards and Professional Activities:
2011 Kopriva Faculty Lectureship in Interdisciplinary Biomedical Sciences (MSU)
2010 Cox Family Faculty Excellence Award (MSU)
2009 Provostâ€™s Award for Undergraduate Research/Creativity Mentoring (MSU)
2008 Charles & Nora L. Wiley Award for Meritorious Research (MSU)
2001 and 2002: Undergraduate Chemistry Society Chemistry Professor of the Year
2001 NSF CAREER Award
1997-1999 California President's Postdoctoral Fellowship
Cloninger Group Overview
My research program is based on key questions in chemical biology. How do cells 'talk' to one another? What are the signaling mechanisms that are used to control cell functions? What processes mediate the adhesions and metastatic migrations of cancer cells?
Using dendrimers to study cancer metastasis.
Many reports suggest that cell surface carbohydrates serve a critical function in malignant transformation and metastasis. We are developing artificial carbohydrate arrays to mimic and interfere with metastasis. Our goal is to advance fundamental knowledge regarding the role of protein-carbohydrate and carbohydrate-carbohydrate interactions in the metastatic spread of cancer. Concurrently, new therapeutic agents to arrest cancer metastasis may also emerge.
The evaluation of dendrimer properties is another area of macromolecular chemistry that is of interest to us. To study the relative locations and the dynamic nature of dendrimer endgroups, we have functionalized dendrimers with varying amounts of spin-labels. EPR spectra of TEMPO-labeled G(4)-PAMAM dendrimers (Figure 4) suggest that termini are randomly distributed on heterogeneously-functionalized dendrimers. Additional EPR studies with other generations of dendrimers and with non-random surface spin-labeling distributions are underway.
Using dendrimers to study multivalent protein-carbohydrate interactions.
We are using dendrimers (macromolecules consisting of a series of branches around an inner core) to study the interaction of carbohydrates with receptor proteins called lectins. Although a wide variety of biological processes including fertilization, development, and the mounting of an immune response rely on protein-carbohydrate interactions for cellular recognition and adhesion (Figure 1), these interactions are not well understood. Because the affinity of lectins for individual saccharide units is relatively weak, the adhesion of lectins to saccharides on the surface of a cell involves multipoint attachment (multivalency).
Goodman, C. K.; Wolfenden, M. L.; Nangia-Makker, P.; Michel, A. K.; Raz, A.; Cloninger, M. J. “Multivalent scaffolds induce galectin-3 aggregation into nanoparticles.” Beilstein J. Org. Chem. 2014, 10, 1570-1577
Chemistry & Biochemistry
103 Chemistry and Biochemistry Building
PO Box 173400
Bozeman, MT 59717