David Mulder, Graduate student

Contact Information:

Montana State University

Department of Chemistry and Biochemistry

230 Chemistry and Biochemistry & Building

Bozeman, MT 59717

Email: dmulder@gmail.com

Research Interests

Growing up in western Michigan and completing an undergraduate degree in chemistry at Calvin College, I came to Bozeman, MT four years ago and am progressing toward a Ph.D. degree in biochemistry. With a wide range of scientific interests centered around structural biology, I am working on the hydrogenase biosynthesis project. This project is particularly exciting as it explores the many unknown details of [FeFe]-hydrogenase maturation and has practical applications toward renewable energy technology. Currently, the focus of my work is characterizing the HydA structural protein from Chlamydomonas reinhardtii. This involves protein purification and characterization via x-ray crystallography, EPR, Mossbauer and x-ray absorption spectroscopies. When I am not spending time in the lab, I enjoy flyfishing, backpacking and skiing in the mountains around Bozeman.

Education

2005

B.S. in Chemistry, Dept. of Chemistry and Biochemistry, Calvin College, Grand Rapids MI.

Research Experience

Summer 2004

2005

REU, Montana State University, Bozeman MT. Professor Robert Szilagyi's lab

INBRE Research Fellowship, Montana State University

Publications

Mulder, DW; Ortillo, DO; Gardenghi, DJ; Naumov, AV; Ruebush, SS; Szilagyi, RK; Huynh B; Broderick, JB; Peters, JW. Activation of HydA^∆EFG requires a preformed [4Fe-4S] cluster. Biochemistry 2009; 48: 6240-6248.

Mcglynn, SE; Mulder, DW; Shepard, SE; Broderick, JB; Peters, JW. Hydrogenase cluster biosynthesis: organometallic chemisty nature's way. Dalton Trans. 2009; 4274-4285.

Posewitz, MC; Mulder, DW; Peters, JW. New Frontiers in Hydrogenase Structure and Biosynthesis. Current Chemical Biology 2008; 2: 178-199.

Sarma R; Mulder, DW; Brecht, E; Szilagy, RK; Seefeldt, LC; Tsuruta, H; Peters, JW. Probing the MgATP-bound conformation of the nitrogenase Fe protein by solution small-angle X-ray scattering. Biochemistry 2007; 46: 14058-14066.

Projects